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Mouse Anti-TWF1 Recombinant Antibody (CBYJT-5394) (CBMAB-T4996-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TWF1 (Twinfilin Actin Binding Protein 1). The antibody can be used for immunoassay techniques, such as ELISA, FC, ICC, IHC, WB.
See all TWF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5394
Antibody Isotype
IgG1
Application
ELISA, FC, ICC, IHC, WB

Basic Information

Immunogen
Purified recombinant fragment of human TWF1 (AA: 335-384 ) expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 335-384

Target

Full Name
TWF1 Gene(Protein Coding) Twinfilin Actin Binding Protein 1
Introduction
TWF1 is twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that TWF1 may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.
Entrez Gene ID
5756
UniProt ID
Q12792
Alternative Names
Twinfilin Actin Binding Protein 1; Protein Tyrosine Kinase 9; PTK9 Protein Tyrosine Kinase 9; Protein A6; PTK9; Twinfilin, Actin-Binding Protein, Homolog 1 (Drosophila)
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).
Biological Process
Biological Process actin filament depolymerization Source:GO_Central1 Publication
Biological Process barbed-end actin filament capping Source:GO_Central1 Publication
Biological Process negative regulation of actin filament polymerization Source:BHF-UCLBy Similarity
Biological Process positive regulation of cardiac muscle hypertrophy Source:Ensembl
Biological Process positive regulation of neuron projection development Source:GO_Central1 Publication
Biological Process regulation of actin phosphorylation Source:BHF-UCL1 Publication
Biological Process regulation of lamellipodium assembly Source:GO_Central1 Publication
Biological Process sequestering of actin monomers Source:BHF-UCLBy Similarity
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).
Involvement in disease
Defects in TWF1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
PTM
Phosphorylated on serine and threonine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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