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Mouse Anti-TWF2 Recombinant Antibody (CBYJT-5404) (CBMAB-T5007-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TWF2 (Twinfilin Actin Binding Protein 2). The antibody can be used for immunoassay techniques, such as WB.
See all TWF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5404
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
PTK9L (AAH00327, 131 a.a. ~ 230 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 131-230

Target

Full Name
TWF2 Gene(Protein Coding) Twinfilin Actin Binding Protein 2
Introduction
TWF2 was identified by its interaction with the catalytic domain of protein kinase C-zeta. TWF2 contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.
Entrez Gene ID
11344
UniProt ID
Q6IBS0
Alternative Names
Twinfilin Actin Binding Protein 2; PTK9L Protein Tyrosine Kinase 9-Like (A6-Related Protein); Protein Tyrosine Kinase 9-Like (A6-Related Protein); Twinfilin-1-Like Protein; A6-Related Protein; PTK9L; Twinfilin, Actin-Binding Protein, Homolog 2 (Drosophila); Twinfilin, Actin-Binding Protein, Homolog 2
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
Biological Process
Biological Process actin filament depolymerization Source:GO_Central1 Publication
Biological Process barbed-end actin filament capping Source:BHF-UCLBy Similarity
Biological Process cell projection organization Source:UniProtKB-KW
Biological Process cellular response to growth factor stimulus Source:BHF-UCL1 Publication
Biological Process cellular response to retinoic acid Source:BHF-UCL1 Publication
Biological Process negative regulation of actin filament polymerization Source:BHF-UCLBy Similarity
Biological Process positive regulation of axon extension Source:BHF-UCL1 Publication
Biological Process positive regulation of lamellipodium assembly Source:BHF-UCL1 Publication
Biological Process positive regulation of neuron projection development Source:BHF-UCL1 Publication
Biological Process regulation of actin cytoskeleton organization Source:BHF-UCL1 Publication
Biological Process regulation of lamellipodium assembly Source:GO_Central1 Publication
Biological Process regulation of microvillus length Source:BHF-UCL1 Publication
Biological Process sequestering of actin monomers Source:BHF-UCLBy Similarity
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, perinuclear region
Cell projection, stereocilium
Perinuclear and G-actin-rich cortical actin structure sublocalization.
PTM
In vitro, phosphorylated by PRKCZ, CK2 and SRC.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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