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Mouse Anti-TWF2 Recombinant Antibody (CBYJT-5406) (CBMAB-T5009-YJ)

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Basic Information

Host Animal
Mouse
Clone
CBYJT-5406
Application
WB, IP, IF, ELISA
Immunogen
Specific for an epitope mapping between amino acids 36-61 within an internal region of Twinfilin-2 of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 36-61
More Infomation

Target

Full Name
TWF2 Gene(Protein Coding) Twinfilin Actin Binding Protein 2
Introduction
TWF2 was identified by its interaction with the catalytic domain of protein kinase C-zeta. TWF2 contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein.
Entrez Gene ID
Human11344
Mouse23999
Rat684352
UniProt ID
HumanQ6IBS0
MouseQ9Z0P5
RatB0BMY7
Alternative Names
Twinfilin Actin Binding Protein 2; PTK9L Protein Tyrosine Kinase 9-Like (A6-Related Protein); Protein Tyrosine Kinase 9-Like (A6-Related Protein); Twinfilin-1-Like Protein; A6-Related Protein; PTK9L; Twinfilin, Actin-Binding Protein, Homolog 2 (Drosophila); Twinfilin, Actin-Binding Protein, Homolog 2
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
Biological Process
Biological Process actin filament depolymerization Source:GO_Central1 Publication
Biological Process barbed-end actin filament capping Source:BHF-UCLBy Similarity
Biological Process cell projection organization Source:UniProtKB-KW
Biological Process cellular response to growth factor stimulus Source:BHF-UCL1 Publication
Biological Process cellular response to retinoic acid Source:BHF-UCL1 Publication
Biological Process negative regulation of actin filament polymerization Source:BHF-UCLBy Similarity
Biological Process positive regulation of axon extension Source:BHF-UCL1 Publication
Biological Process positive regulation of lamellipodium assembly Source:BHF-UCL1 Publication
Biological Process positive regulation of neuron projection development Source:BHF-UCL1 Publication
Biological Process regulation of actin cytoskeleton organization Source:BHF-UCL1 Publication
Biological Process regulation of lamellipodium assembly Source:GO_Central1 Publication
Biological Process regulation of microvillus length Source:BHF-UCL1 Publication
Biological Process sequestering of actin monomers Source:BHF-UCLBy Similarity
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, perinuclear region
Cell projection, stereocilium
Perinuclear and G-actin-rich cortical actin structure sublocalization.
PTM
In vitro, phosphorylated by PRKCZ, CK2 and SRC.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TWF2 Matched Antibody Pair (1288) (CAT#: APMAB-1288LY)

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TWF2 Matched Antibody Pair (1288) (CAT#: APMAB-1288LY)

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Mouse Anti-TWF2 Recombinant Antibody (CBYJT-5405) (CAT#: CBMAB-T5008-YJ)

Mouse Anti-TWF2 Recombinant Antibody (2B5) (CAT#: CBMAB-A7210-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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