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Mouse Anti-TXK Recombinant Antibody (674801) (CBMAB-R4083-CN)

This product is a Mouse antibody that recognizes TXK. The antibody 674801 can be used for immunoassay techniques such as: WB.
See all TXK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
674801
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E.coli-derived recombinant human RLK/TXK, Trp150-Val246, Accession # P42681
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose
Concentration
LYOPH

Target

Full Name
TXK tyrosine kinase
Introduction
TXK (TXK Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TXK include Behcet Syndrome and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Akt Signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TEC.
Entrez Gene ID
7294
UniProt ID
P42681
Alternative Names
TXK Tyrosine Kinase; PTK4 Protein Tyrosine Kinase 4; Protein-Tyrosine Kinase 4; Resting Lymphocyte Kinase; EC 2.7.10.2; PTK4; RLK;
Function
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation leads to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1 (PubMed:11859127, PubMed:17177976).
Within the complex, phosphorylates both PARP1 and EEF1A1 (PubMed:17177976).
Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
Biological Process
Biological Process activation of phospholipase C activity Source:UniProtKB
Biological Process adaptive immune response Source:UniProtKB
Biological Process integrin-mediated signaling pathway Source:GO_Central1 Publication
Biological Process positive regulation of cytokine production Source:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase II Source:NTNU_SB1 Publication
Biological Process positive regulation of type II interferon production Source:UniProtKB2 Publications
Biological Process positive regulation of type II interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:UniProtKB2 Publications
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of platelet activation Source:GO_Central1 Publication
Biological Process T cell receptor signaling pathway Source:UniProtKB
Biological Process tissue regeneration Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Cell membrane
Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.
PTM
Phosphorylated at Tyr-420 by FYN. Autophosphorylation at Tyr-91 is critical for the activation of TXK, leading to the up-regulation of IFN-gamma gene transcription.
The cysteine string at the N-terminus is palmitoylated and required for the proper subcellular location.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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