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Mouse Anti-TXNL4A Recombinant Antibody (1C4) (CBMAB-A9681-LY)

The product is antibody recognizes TXNL4A. The antibody 1C4 immunoassay techniques such as: WB, ELISA.
See all TXNL4A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TXNL4A (AAH01046, 1 a.a. ~ 142 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
thioredoxin-like 4A
Entrez Gene ID
10907
UniProt ID
P83876
Alternative Names
DIB1; DIM1; HsT161; TXNL4; U5-15kD
Function
Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication
Biological Process spliceosomal complex assembly Source:UniProtKB1 Publication
Cellular Location
Nucleus
Involvement in disease
Burn-McKeown syndrome (BMKS):
A disease characterized by choanal atresia, sensorineural deafness, cardiac defects, and typical craniofacial dysmorphism consisting of narrow palpebral fissures, coloboma of the lower eyelids, prominent nose with high nasal bridge, short philtrum, cleft lip and/or palate, and large and protruding ears. Intellectual development is normal.
PTM
The disulfide bond seen in structures determined by X-ray crystallography (PubMed:10610776) and NMR (PubMed:12911302) is not essential for protein folding and function (PubMed:12911302 and PubMed:17467737).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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