Mouse Anti-TXNL4A Recombinant Antibody (CBYJT-5477) (CBMAB-T5090-YJ)

Name: Mouse Anti-TXNL4A Recombinant Antibody (CBYJT-5477)
SKU: CBMAB-T5090-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-5477

Application

ELISA, WB

Immunogen

Full length recombinant corresponding to aa1-142 from human TXNL4A (AAH01046) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-142

More Infomation

Target

Full Name

thioredoxin-like 4A

Introduction

TXNL4A is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. TXNL4A contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2.

Entrez Gene ID

10907

UniProt ID

P83876

Alternative Names

Thioredoxin Like 4A; Spliceosomal U5 SnRNP-Specific 15 KDa Protein; Thioredoxin-Like U5 SnRNP Protein U5-15kD; DIM1 Protein Homolog; Thioredoxin-Like 4; TXNL4; DIM1; Thioredoxin-Like Protein 4A

Function

Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

Biological Process

Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication
Biological Process spliceosomal complex assembly Source:UniProtKB1 Publication

Cellular Location

Nucleus

Involvement in disease

Burn-McKeown syndrome (BMKS):
A disease characterized by choanal atresia, sensorineural deafness, cardiac defects, and typical craniofacial dysmorphism consisting of narrow palpebral fissures, coloboma of the lower eyelids, prominent nose with high nasal bridge, short philtrum, cleft lip and/or palate, and large and protruding ears. Intellectual development is normal.

PTM

The disulfide bond seen in structures determined by X-ray crystallography (PubMed:10610776) and NMR (PubMed:12911302) is not essential for protein folding and function (PubMed:12911302 and PubMed:17467737).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TXNL4A Recombinant Antibody (1C4) (CAT#: CBMAB-A9681-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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