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Mouse Anti-TXNL4A Recombinant Antibody (CBYJT-5477) (CBMAB-T5090-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TXNL4A (Thioredoxin Like 4A). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TXNL4A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5477
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-142 from human TXNL4A (AAH01046) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-142

Target

Full Name
thioredoxin-like 4A
Introduction
TXNL4A is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. TXNL4A contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2.
Entrez Gene ID
10907
UniProt ID
P83876
Alternative Names
Thioredoxin Like 4A; Spliceosomal U5 SnRNP-Specific 15 KDa Protein; Thioredoxin-Like U5 SnRNP Protein U5-15kD; DIM1 Protein Homolog; Thioredoxin-Like 4; TXNL4; DIM1; Thioredoxin-Like Protein 4A
Function
Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process mRNA splicing, via spliceosome Source:UniProtKB1 Publication
Biological Process RNA splicing, via transesterification reactions Source:UniProtKB1 Publication
Biological Process spliceosomal complex assembly Source:UniProtKB1 Publication
Cellular Location
Nucleus
Involvement in disease
Burn-McKeown syndrome (BMKS):
A disease characterized by choanal atresia, sensorineural deafness, cardiac defects, and typical craniofacial dysmorphism consisting of narrow palpebral fissures, coloboma of the lower eyelids, prominent nose with high nasal bridge, short philtrum, cleft lip and/or palate, and large and protruding ears. Intellectual development is normal.
PTM
The disulfide bond seen in structures determined by X-ray crystallography (PubMed:10610776) and NMR (PubMed:12911302) is not essential for protein folding and function (PubMed:12911302 and PubMed:17467737).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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