Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5484) (CBMAB-T5098-YJ)

Name: Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5484)
SKU: CBMAB-T5098-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-5484

Application

WB, ELISA, ICC, IF

Immunogen

Recombinant human TXNRD1 (161-647aa) purified from E. coli

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 161-647

More Infomation

Target

Full Name

TXNRD1 Gene(Protein Coding) Thioredoxin Reductase 1

Introduction

TXNRD1 belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. TXNRD1 is an ubiquitously expressed, cytosolic form of TrxR, which plays a role as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination.

Entrez Gene ID

7296

UniProt ID

Q16881

Alternative Names

Thioredoxin Reductase 1; Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein; Gene Associated With Retinoic And IFN-Induced Mortality 12 Protein; KM-102-Derived Reductase-Like Factor; Thioredoxin Reductase TR1; EC 1.8.1.9; GRIM-12; TR; Testis Tissue Sperm-Binding Protein Li 46a; Thioredoxin Reductase 1, Cytoplasmic

Function

Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704).
Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
Isoform 1
Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.
Isoform 4
Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.
Isoform 5
Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063).
Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).

Biological Process

Biological Process cell population proliferation Source:Ensembl
Biological Process cell redox homeostasis Source:GO_Central1 Publication
Biological Process mesoderm formation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Isoform 1
Cytoplasm
Isoform 4
Cytoplasm
Nucleus
Isoform 5
Cytoplasm

PTM

Isoform 5
The N-terminus is blocked.
ISGylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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