TXNRD1
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
Full Name
TXNRD1 Gene(Protein Coding) Thioredoxin Reductase 1
Function
Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704).
Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
Isoform 1
Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.
Isoform 4
Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.
Isoform 5
Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063).
Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).
Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
Isoform 1
Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.
Isoform 4
Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.
Isoform 5
Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063).
Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).
Biological Process
Biological Process cell population proliferation Source:Ensembl
Biological Process cell redox homeostasis Source:GO_Central1 Publication
Biological Process mesoderm formation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process cell redox homeostasis Source:GO_Central1 Publication
Biological Process mesoderm formation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cytoplasm
Isoform 4
Cytoplasm
Nucleus
Isoform 5
Cytoplasm
Cytoplasm
Isoform 4
Cytoplasm
Nucleus
Isoform 5
Cytoplasm
PTM
Isoform 5
The N-terminus is blocked.
ISGylated.
The N-terminus is blocked.
ISGylated.
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Anti-TXNRD1 antibodies
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CompareTarget: TXNRD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: D1T3D
Application*: WB, P
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human, Rat
Clone: CBYJT-5490
Application*: WB, IS, MC
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5488
Application*: E, IP
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5487
Application*: IP
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5486
Application*: E, IP
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-5485
Application*: E, IH, IP, WB
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-5484
Application*: WB, E, IC, IF
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5483
Application*: E, IP, WB
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5482
Application*: IF, IC
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 19A1
Application*: WB, IP, E, F, IC, IF
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5481
Application*: E, IH, WB
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5480
Application*: E, IP, WB
Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5478
Application*: F, IC, IF
Target: Txnrd1
Sensitivity: 0.019 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: TXNRD1
Sensitivity: 0.057 mU/mL
Detection Range: 0.1-40 mU/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: TXNRD1
Expressed Host: E. coli
Sequence: Amino Acid: 151-647
Tag: His Tag
Target: TXNRD1
Expressed Host: E. coli
Sequence: Amino Acid: 161-647
Tag: His Tag
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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