TXNRD1

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]
Full Name
TXNRD1 Gene(Protein Coding) Thioredoxin Reductase 1
Function
Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704).
Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
Isoform 1
Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.
Isoform 4
Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.
Isoform 5
Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063).
Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).
Biological Process
Biological Process cell population proliferation Source:Ensembl
Biological Process cell redox homeostasis Source:GO_Central1 Publication
Biological Process mesoderm formation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cytoplasm
Isoform 4
Cytoplasm
Nucleus
Isoform 5
Cytoplasm
PTM
Isoform 5
The N-terminus is blocked.
ISGylated.
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Anti-TXNRD1 antibodies

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Rabbit Anti-TXNRD1 Recombinant Antibody (D1T3D) (CBMAB-CP2880-LY)

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Target: TXNRD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: D1T3D
Application*: WB, P
Datasheet SDS

Mouse Anti-Txnrd1 Recombinant Antibody (CBYJT-5490) (CBMAB-T5104-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human, Rat
Clone: CBYJT-5490
Application*: WB, IS, MC
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5488) (CBMAB-T5102-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5488
Application*: E, IP
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5487) (CBMAB-T5101-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5487
Application*: IP
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5486) (CBMAB-T5100-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5486
Application*: E, IP
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5485) (CBMAB-T5099-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-5485
Application*: E, IH, IP, WB
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5484) (CBMAB-T5098-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-5484
Application*: WB, E, IC, IF
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5483) (CBMAB-T5097-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5483
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5482) (CBMAB-T5096-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5482
Application*: IF, IC
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (19A1) (CBMAB-T5095-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 19A1
Application*: WB, IP, E, F, IC, IF
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5481) (CBMAB-T5094-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5481
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5480) (CBMAB-T5093-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5480
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-TXNRD1 Recombinant Antibody (CBYJT-5478) (CBMAB-T5091-YJ)

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Target: TXNRD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5478
Application*: F, IC, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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