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Mouse Anti-TXNRD1 Recombinant Antibody (19A1) (CBMAB-T5095-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TXNRD1 (Thioredoxin Reductase 1). The antibody can be used for immunoassay techniques, such as WB, IP, ELISA, FC, ICC, IF.
See all TXNRD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
19A1
Antibody Isotype
IgG1
Application
WB, IP, ELISA, FC, ICC, IF

Basic Information

Immunogen
Recombinant full length protein (Human).
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TXNRD1 Gene(Protein Coding) Thioredoxin Reductase 1
Introduction
TXNRD1 belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. TXNRD1 is an ubiquitously expressed, cytosolic form of TrxR, which plays a role as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination.
Entrez Gene ID
7296
UniProt ID
Q16881
Alternative Names
Thioredoxin Reductase 1; Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein; Gene Associated With Retinoic And IFN-Induced Mortality 12 Protein; KM-102-Derived Reductase-Like Factor; Thioredoxin Reductase TR1; EC 1.8.1.9; GRIM-12; TR; Testis Tissue Sperm-Binding Protein Li 46a; Thioredoxin Reductase 1, Cytoplasmic
Function
Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704).
Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
Isoform 1
Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions.
Isoform 4
Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2.
Isoform 5
Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063).
Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665).
Biological Process
Biological Process cell population proliferation Source:Ensembl
Biological Process cell redox homeostasis Source:GO_Central1 Publication
Biological Process mesoderm formation Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cytoplasm
Isoform 4
Cytoplasm
Nucleus
Isoform 5
Cytoplasm
PTM
Isoform 5
The N-terminus is blocked.
ISGylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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