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Mouse Anti-TYMS Recombinant Antibody (CBYJT-5522) (CBMAB-T5140-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TYMS (Thymidylate Synthetase). The antibody can be used for immunoassay techniques, such as ELISA, FC, IF, IP, WB.
See all TYMS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5522
Antibody Isotype
IgG1, κ
Application
ELISA, FC, IF, IP, WB

Basic Information

Immunogen
Recombinant human TS enzyme (36kD). Cellular Localization: Nuclear and cytoplasmic
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TYMS Gene(Protein Coding) Thymidylate Synthetase
Introduction
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of TYMS and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in TYMS may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy.
Entrez Gene ID
7298
UniProt ID
P04818
Alternative Names
Thymidylate Synthetase; EC 2.1.1.45; TSase; TS; Thymidylate Synthase; HST422; TMS
Function
Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Biological Process
Biological Process aging Source:Ensembl
Biological Process cartilage development Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process developmental growth Source:Ensembl
Biological Process DNA biosynthetic process Source:BHF-UCL1 Publication
Biological Process dTMP biosynthetic process Source:CAFA3 Publications
Biological Process dTTP biosynthetic process Source:UniProtKB-UniPathway
Biological Process intestinal epithelial cell maturation Source:Ensembl
Biological Process liver regeneration Source:Ensembl
Biological Process methylation Source:UniProtKB-KW
Biological Process negative regulation of translation Source:CAFA1 Publication
Biological Process response to cytokine Source:Ensembl
Biological Process response to ethanol Source:Ensembl
Biological Process response to folic acid Source:Ensembl
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to organophosphorus Source:UniProtKB1 Publication
Biological Process response to progesterone Source:Ensembl
Biological Process response to toxic substance Source:Ensembl
Biological Process response to vitamin A Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process tetrahydrofolate interconversion Source:BHF-UCL1 Publication
Biological Process uracil metabolic process Source:Ensembl
Cellular Location
Nucleus
Cytoplasm
Mitochondrion
Mitochondrion matrix
Mitochondrion inner membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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