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TYMS

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Full Name
TYMS Gene(Protein Coding) Thymidylate Synthetase
Function
Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Biological Process
Biological Process aging Source:Ensembl
Biological Process cartilage development Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process developmental growth Source:Ensembl
Biological Process DNA biosynthetic process Source:BHF-UCL1 Publication
Biological Process dTMP biosynthetic process Source:CAFA3 Publications
Biological Process dTTP biosynthetic process Source:UniProtKB-UniPathway
Biological Process intestinal epithelial cell maturation Source:Ensembl
Biological Process liver regeneration Source:Ensembl
Biological Process methylation Source:UniProtKB-KW
Biological Process negative regulation of translation Source:CAFA1 Publication
Biological Process response to cytokine Source:Ensembl
Biological Process response to ethanol Source:Ensembl
Biological Process response to folic acid Source:Ensembl
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to organophosphorus Source:UniProtKB1 Publication
Biological Process response to progesterone Source:Ensembl
Biological Process response to toxic substance Source:Ensembl
Biological Process response to vitamin A Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process tetrahydrofolate interconversion Source:BHF-UCL1 Publication
Biological Process uracil metabolic process Source:Ensembl
Cellular Location
Nucleus
Cytoplasm
Mitochondrion
Mitochondrion matrix
Mitochondrion inner membrane
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Anti-TYMS antibodies

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Mouse Anti-TYMS Recombinant Antibody (TS106 + TMS715) (CBMAB-T5149-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: TS106 + TMS715
Application*: WB, F, IC, IF, IP, P, C, MC
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (TS106) (CBMAB-CP2759-LY)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: TS106
Application*: WB
Datasheet SDS

Rabbit Anti-TYMS Recombinant Antibody (D26G11) (CBMAB-CP2758-LY)

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Target: TYMS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: D26G11
Application*: WB, IP
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (2B2) (CBMAB-A9686-LY)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B2
Application*: WB, E
Datasheet SDS

Rabbit Anti-TYMS Recombinant Antibody (CBYJT-5531) (CBMAB-T5154-YJ)

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Target: TYMS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYJT-5531
Application*: WB, P, IF, F
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5529) (CBMAB-T5152-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5529
Application*: IP, WB, P, E
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5528) (CBMAB-T5151-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5528
Application*: E, IB, IH, IP
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (TYSY9) (CBMAB-T5150-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: TYSY9
Application*: P, IF, IC
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5527) (CBMAB-T5148-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5527
Application*: WB, E, IC, IF, IP, P, C
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5526) (CBMAB-T5147-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5526
Application*: E, F, IF, IP, WB
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5525) (CBMAB-T5144-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5525
Application*: F, IF, IP, WB
Datasheet SDS

Rabbit Anti-TYMS Recombinant Antibody (SP112) (CBMAB-T5143-YJ)

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Target: TYMS
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP112
Application*: P
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5524) (CBMAB-T5142-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYJT-5524
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5523) (CBMAB-T5141-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-5523
Application*: E, IC, IF, WB
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5522) (CBMAB-T5140-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5522
Application*: E, F, IF, IP, WB
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5521) (CBMAB-T5139-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5521
Application*: E, F, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5520) (CBMAB-T5138-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5520
Application*: E, F, IF, IH, IP, WB
Datasheet SDS

Mouse Anti-TYMS Recombinant Antibody (CBYJT-5519) (CBMAB-T5137-YJ)

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Target: TYMS
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-5519
Application*: E, F, IF, IP, WB
Datasheet SDS

TYMS Matched Antibody Pair (1290) (APMAB-1290LY)

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Target: TYMS
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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