TYMS

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

TYMS Gene(Protein Coding) Thymidylate Synthetase

Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.

Biological Process aging Source:Ensembl
Biological Process cartilage development Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process developmental growth Source:Ensembl
Biological Process DNA biosynthetic process Source:BHF-UCL1 Publication
Biological Process dTMP biosynthetic process Source:CAFA3 Publications
Biological Process dTTP biosynthetic process Source:UniProtKB-UniPathway
Biological Process intestinal epithelial cell maturation Source:Ensembl
Biological Process liver regeneration Source:Ensembl
Biological Process methylation Source:UniProtKB-KW
Biological Process negative regulation of translation Source:CAFA1 Publication
Biological Process response to cytokine Source:Ensembl
Biological Process response to ethanol Source:Ensembl
Biological Process response to folic acid Source:Ensembl
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to organophosphorus Source:UniProtKB1 Publication
Biological Process response to progesterone Source:Ensembl
Biological Process response to toxic substance Source:Ensembl
Biological Process response to vitamin A Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process tetrahydrofolate interconversion Source:BHF-UCL1 Publication
Biological Process uracil metabolic process Source:Ensembl

Nucleus
Cytoplasm
Mitochondrion
Mitochondrion matrix
Mitochondrion inner membrane