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Rabbit Anti-TYMS Recombinant Antibody (D26G11) (CBMAB-CP2758-LY)

The product is antibody recognizes TYMS. The antibody D26G11 immunoassay techniques such as: WB,IP.
See all TYMS antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Hamster, Monkey
Clone
D26G11
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to central residues of human Thymidylate Synthase protein.
Specificity
Human, Mouse, Rat, Hamster, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TYMS Gene(Protein Coding) Thymidylate Synthetase
Introduction
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Entrez Gene ID
Human7298
Mouse22171
Rat29261
Monkey697580
Hamster100754276
UniProt ID
HumanP04818
MouseP07607
RatP45352
MonkeyF6ZR77
HamsterG3IFY1
Alternative Names
Thymidylate Synthetase; EC 2.1.1.45; TSase; TS; Thymidylate Synthase; HST422; TMS;
Function
Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
Biological Process
Biological Process aging Source:Ensembl
Biological Process cartilage development Source:Ensembl
Biological Process circadian rhythm Source:Ensembl
Biological Process developmental growth Source:Ensembl
Biological Process DNA biosynthetic process Source:BHF-UCL1 Publication
Biological Process dTMP biosynthetic process Source:CAFA3 Publications
Biological Process dTTP biosynthetic process Source:UniProtKB-UniPathway
Biological Process intestinal epithelial cell maturation Source:Ensembl
Biological Process liver regeneration Source:Ensembl
Biological Process methylation Source:UniProtKB-KW
Biological Process negative regulation of translation Source:CAFA1 Publication
Biological Process response to cytokine Source:Ensembl
Biological Process response to ethanol Source:Ensembl
Biological Process response to folic acid Source:Ensembl
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to organophosphorus Source:UniProtKB1 Publication
Biological Process response to progesterone Source:Ensembl
Biological Process response to toxic substance Source:Ensembl
Biological Process response to vitamin A Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process tetrahydrofolate interconversion Source:BHF-UCL1 Publication
Biological Process uracil metabolic process Source:Ensembl
Cellular Location
Nucleus
Cytoplasm
Mitochondrion
Mitochondrion matrix
Mitochondrion inner membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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