Mouse Anti-UACA Recombinant Antibody (A-4) (CBMAB-N4347-WJ)

Name: Mouse Anti-UACA Recombinant Antibody (A-4)
SKU: CBMAB-N4347-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A-4

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats

Introduction

This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]

Entrez Gene ID

55075

UniProt ID

Q9BZF9

Alternative Names

Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats; Nucling; Nuclear Membrane Binding Protein; KIAA1561;

Function

Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).

Biological Process

Biological Process apoptotic signaling pathway Source:InterPro
Biological Process negative regulation of NIK/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:GO_Central1 Publication

Cellular Location

Nucleus
Cytoplasm
Cytoplasm, cytoskeleton
Expressed diffusely in cytoplasm.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-UACA Recombinant Antibody (A-5) (CAT#: CBMAB-N4348-WJ)

Isotype control

For research use only. Not intended for any clinical use.

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