Mouse Anti-UACA Recombinant Antibody (UACA/1222) (CBMAB-U0013-FY)

Name: Mouse Anti-UACA Recombinant Antibody (UACA/1222)
SKU: CBMAB-U0013-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

UACA/1222

Application

WB, FC, IF, IHC-P

Immunogen

Recombinant human UACA protein

Specificity

Human, Mouse

Antibody Isotype

IgG1, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats

Introduction

This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).

Entrez Gene ID

Human	55075
Mouse	72565

UniProt ID

Human	Q9BZF9
Mouse	Q8CGB3

Alternative Names

NUCLING

Function

Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).

Biological Process

Biological Process apoptotic signaling pathway Source:InterPro
Biological Process negative regulation of NIK/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:GO_Central1 Publication

Cellular Location

Nucleus
Cytoplasm
Cytoplasm, cytoskeleton
Expressed diffusely in cytoplasm.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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