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Mouse Anti-UACA Recombinant Antibody (CBFYU-012) (CBMAB-U0012-FY)

This product is mouse antibody that recognizes UACA. The antibody CBFYU-012 can be used for immunoassay techniques such as: FC, IF, IHC-P, IHC-Fr, CyTOF.
See all UACA antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBFYU-012
Antibody Isotype
IgG1, к
Application
FC, IF, IHC-P, IHC-Fr, CyTOF

Basic Information

Immunogen
Nuclei of myeloid leukemia biopsy cells
Specificity
Human, Mouse
Antibody Isotype
IgG1, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Uveal Autoantigen With Coiled-Coil Domains And Ankyrin Repeats
Introduction
This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Entrez Gene ID
Human55075
Mouse72565
UniProt ID
HumanQ9BZF9
MouseQ8CGB3
Alternative Names
NUCLING
Function
Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity).
Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity).
Biological Process
Biological Process apoptotic signaling pathway Source:InterPro
Biological Process negative regulation of NIK/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm
Cytoplasm, cytoskeleton
Expressed diffusely in cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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