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Rabbit Anti-UBD Recombinant Antibody (CBFYU-060) (CBMAB-U0060-FY)

This product is rabbit antibody that recognizes UBD. The antibody CBFYU-060 can be used for immunoassay techniques such as: ELISA, WB.
See all UBD antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYU-060
Antibody Isotype
IgG2a, к
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant protein corresponding to aa1-165 from UBD (NP_006389.1) with GST tag. MW of the GST tag alone is 26 kD.
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-165

Target

Full Name
Ubiquitin D
Introduction
Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many cancer types. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2).
Entrez Gene ID
10537
UniProt ID
O15205
Alternative Names
FAT10; UBD-3; GABBR1
Function
Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).
Biological Process
Biological Process aggresome assembly Source:UniProtKB1 Publication
Biological Process myeloid dendritic cell differentiation Source:UniProtKB1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process protein modification by small protein conjugation Source:UniProtKB1 Publication
Biological Process protein ubiquitination Source:UniProtKB2 Publications
Biological Process proteolysis Source:UniProtKB1 Publication
Biological Process regulation of mitotic cell cycle phase transition Source:UniProtKB1 Publication
Biological Process response to tumor necrosis factor Source:UniProtKB1 Publication
Biological Process response to type II interferon Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Nucleus
Cytoplasm
Accumulates in aggresomes under proteasome inhibition conditions.
PTM
Can be acetylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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