Rabbit Anti-UBE2K Recombinant Antibody (D27C4) (CBMAB-H3896-FY)

Name: Rabbit Anti-UBE2K Recombinant Antibody (D27C4)
SKU: CBMAB-H3896-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

D27C4

Application

WB, IP

Specificity

Human, Mouse, Rat, Monkey, Cattle

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Ubiquitin Conjugating Enzyme E2 K

Introduction

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.

Entrez Gene ID

Human	3093
Mouse	53323
Rat	289623
Monkey	699734
Cattle	281225

UniProt ID

Human	P61086
Mouse	P61087
Rat	D3ZXS8
Monkey	F6U8R5
Cattle	P61085

Alternative Names

Ubiquitin Conjugating Enzyme E2 K; Ubiquitin-Conjugating Enzyme E2K (UBC1 Homolog, Yeast); Ubiquitin-Conjugating Enzyme E2(25K); E2 Ubiquitin-Conjugating Enzyme K; Huntingtin-Interacting Protein 2; Ubiquitin Carrier Protein; Ubiquitin-Protein Ligase; HIP-2; HIP2; LIG; Ubiquitin-Conjugating Enzyme E2-25 KDA; Ubiquitin-Conjugating Enzyme E2-25 KDa

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

Biological Process

Biological Process cellular response to interferon-beta Source:UniProtKB1 Publication
Biological Process free ubiquitin chain polymerization Source:UniProtKB1 Publication
Biological Process positive regulation of peptidyl-threonine phosphorylation Source:UniProtKB1 Publication
Biological Process positive regulation of tumor necrosis factor-mediated signaling pathway Source:FlyBase1 Publication
Biological Process positive regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process regulation of proteasomal ubiquitin-dependent protein catabolic process Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:ProtInc1 Publication

Cellular Location

Cytoplasm

PTM

Sumoylation at Lys-14 impairs catalytic activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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