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Rabbit Anti-UBE2M Recombinant Antibody (D13D7) (CBMAB-CP2918-LY)

The product is antibody recognizes UBE2M. The antibody D13D7 immunoassay techniques such as: WB,IP.
See all UBE2M antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D13D7
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys36 of human Ubc12 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
UBE2M
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human9040
Mouse22192
Rat361509
Monkey712206
UniProt ID
HumanP61081
MouseP61082
RatD3ZNQ6
MonkeyF6Z6D4
Alternative Names
Ubiquitin Conjugating Enzyme E2 M; Ubiquitin-Conjugating Enzyme E2M (UBC12 Homolog; Yeast); NEDD8 Carrier Protein; NEDD8 Protein Ligase; UBC12; Ubiquitin-Conjugating Enzyme E2M (Homologous To Yeast UBC12); Ubiquitin-Conjugating Enzyme E2 M; Ubiquitin-Conjugating Enzyme E2M; Ubiquitin Conjugating Enzyme E2M;
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Biological Process
Biological Process positive regulation of neuron apoptotic process Source:Ensembl
Biological Process post-translational protein modification Source:Reactome
Biological Process protein modification process Source:UniProtKB1 Publication
Biological Process protein neddylation Source:UniProtKB1 Publication
Cellular Location
cytosol
nucleoplasm
nucleus
PTM
The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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