UBE2M

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Full Name
UBE2M
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Biological Process
Biological Process positive regulation of neuron apoptotic process Source:Ensembl
Biological Process post-translational protein modification Source:Reactome
Biological Process protein modification process Source:UniProtKB1 Publication
Biological Process protein neddylation Source:UniProtKB1 Publication
Cellular Location
cytosol
nucleoplasm
nucleus
PTM
The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
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Anti-UBE2M antibodies

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Mouse Anti-UBE2M Antibody (1D12) (CBMAB-1750CQ)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1D12
Application*: E, M
Datasheet SDS

Mouse Anti-UBE2M Antibody (V2-3197) (CBMAB-1749CQ)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-3197
Application*: E, M
Datasheet SDS

Mouse Anti-UBE2M Antibody (14D7) (CBMAB-1748CQ)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14D7
Application*: E, M
Datasheet SDS

Mouse Anti-UBE2M Antibody (11H11) (CBMAB-1747CQ)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11H11
Application*: E, M
Datasheet SDS

Mouse Anti-UBE2M Antibody (11F12) (CBMAB-1746CQ)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11F12
Application*: E, M
Datasheet SDS

Rabbit Anti-UBE2M Recombinant Antibody (D13D7) (CBMAB-CP2918-LY)

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Target: UBE2M
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D13D7
Application*: WB, IP
Datasheet SDS

Mouse Anti-UBE2M Recombinant Antibody (3C4) (CBMAB-A9721-LY)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C4
Application*: WB, E
Datasheet SDS

Mouse Anti-UBE2M Recombinant Antibody (1G9) (CBMAB-A9720-LY)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G9
Application*: WB, E
Datasheet SDS

Mouse Anti-UBE2M Recombinant Antibody (CBFYU-137) (CBMAB-U0137-FY)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-137
Application*: WB
Datasheet SDS

Mouse Anti-UBE2M Recombinant Antibody (CBFYU-135) (CBMAB-U0135-FY)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog
Clone: CBFYU-135
Application*: WB, IF
Datasheet SDS

Mouse Anti-UBE2M Recombinant Antibody (CBFYU-134) (CBMAB-U0134-FY)

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Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYU-134
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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