UBE2M
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]
Full Name
UBE2M
Function
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.
Biological Process
Biological Process positive regulation of neuron apoptotic process Source:Ensembl
Biological Process post-translational protein modification Source:Reactome
Biological Process protein modification process Source:UniProtKB1 Publication
Biological Process protein neddylation Source:UniProtKB1 Publication
Biological Process post-translational protein modification Source:Reactome
Biological Process protein modification process Source:UniProtKB1 Publication
Biological Process protein neddylation Source:UniProtKB1 Publication
Cellular Location
cytosol
nucleoplasm
nucleus
nucleoplasm
nucleus
PTM
The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
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Anti-UBE2M antibodies
+ Filters
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1D12
Application*: E, M
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: V2-3197
Application*: E, M
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14D7
Application*: E, M
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11H11
Application*: E, M
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11F12
Application*: E, M
Target: UBE2M
Expressed Host: E. coli
Sequence: Amino Acid: 1-183
Tag: GST Tag
Target: UBE2M
Expressed Host: E. coli
Sequence: Amino Acid: 1-183
Target: UBE2M
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D13D7
Application*: WB, IP
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C4
Application*: WB, E
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1G9
Application*: WB, E
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYU-137
Application*: WB
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Dog
Clone: CBFYU-135
Application*: WB, IF
Target: UBE2M
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYU-134
Application*: E, IF, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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