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Rabbit Anti-UBE2S Recombinant Antibody (CBFYU-155) (CBMAB-U0155-FY)

This product is rabbit antibody that recognizes UBE2S. The antibody CBFYU-155 can be used for immunoassay techniques such as: WB, IP.
See all UBE2S antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Cattle, Dog
Clone
CBFYU-155
Application
WB, IP

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Mouse, Rat, Monkey, Cattle, Dog
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Conjugating Enzyme E2 S
Introduction
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins.
Entrez Gene ID
Human27338
Mouse77891
Rat292588
Monkey700592
Cattle617703
Dog403671
UniProt ID
HumanQ16763
MouseQ921J4
RatD3Z8W5
MonkeyF7G0V2
CattleQ1RML1
DogA0A8C0M095
Alternative Names
EPF5; E2EPF; E2-EPF
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338).
Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151).
Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549).
In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874).
Biological Process
Biological Process anaphase-promoting complex-dependent catabolic process Source:UniProtKB2 Publications
Biological Process cell division Source:UniProtKB-KW
Biological Process exit from mitosis Source:UniProtKB1 Publication
Biological Process free ubiquitin chain polymerization Source:UniProtKB1 Publication
Biological Process positive regulation of ubiquitin protein ligase activity Source:UniProtKB2 Publications
Biological Process protein K11-linked ubiquitination Source:UniProtKB3 Publications
Biological Process protein K27-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K29-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K6-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:ProtInc1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
anaphase-promoting complex
cytosol
nucleoplasm
nucleus
PTM
Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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