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Mouse Anti-UBN1 Recombinant Antibody (CBFYU-192) (CBMAB-U0192-FY)

This product is mouse antibody that recognizes UBN1. The antibody CBFYU-192 can be used for immunoassay techniques such as: WB.
See all UBN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-192
Application
WB

Basic Information

Immunogen
Partial sequence of recombinant full length protein to human ubinuclein 1
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubinuclein 1
Introduction
The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3.
Entrez Gene ID
29855
UniProt ID
Q9NPG3
Alternative Names
VT; VT4
Function
Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Biological Process
Biological Process chromatin organization Source:GO_Central1 Publication
Biological Process nucleosome assembly Source:GO_Central1 Publication
Cellular Location
Nucleus, nucleoplasm
Nucleus, PML body
Cell junction, tight junction
Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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