Mouse Anti-UBN1 Recombinant Antibody (CBFYU-192) (CBMAB-U0192-FY)

Name: Mouse Anti-UBN1 Recombinant Antibody (CBFYU-192)
SKU: CBMAB-U0192-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYU-192

Application

Immunogen

Partial sequence of recombinant full length protein to human ubinuclein 1

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

0.05% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Ubinuclein 1

Introduction

The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3.

Entrez Gene ID

29855

UniProt ID

Q9NPG3

Alternative Names

VT; VT4

Function

Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.

Biological Process

Biological Process chromatin organization Source:GO_Central1 Publication
Biological Process nucleosome assembly Source:GO_Central1 Publication

Cellular Location

Nucleus, nucleoplasm
Nucleus, PML body
Cell junction, tight junction
Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-UBN1 Recombinant Antibody (UBN1G12) (CAT#: CBMAB-U0193-FY)

Mouse Anti-UBN1 Recombinant Antibody (CBFYU-194) (CAT#: CBMAB-U0194-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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