UBN1

Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3.

Full Name

Ubinuclein 1

Function

Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.

Biological Process

Biological Process chromatin organization Source:GO_Central1 Publication
Biological Process nucleosome assembly Source:GO_Central1 Publication

Cellular Location

Nucleus, nucleoplasm
Nucleus, PML body
Cell junction, tight junction
Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.

Anti-UBN1 antibodies

Mouse Anti-UBN1 Recombinant Antibody (CBFYU-192) (CBMAB-U0192-FY)

Datasheet

SDS

Target: UBN1

Host: Mouse

Specificity: Human

Clone: CBFYU-192

Application*: WB

Mouse Anti-UBN1 Recombinant Antibody (UBN1G12) (CBMAB-U0193-FY)

Datasheet

SDS

Target: UBN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: UBN1G12

Application*: DB, WB

Mouse Anti-UBN1 Recombinant Antibody (CBFYU-194) (CBMAB-U0194-FY)

Datasheet

SDS

Target: UBN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYU-194

Application*: WB, IP, F

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)