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Mouse Anti-UGDH Recombinant Antibody (1B7) (CBMAB-C4533-CN)

This product is a Mouse antibody that recognizes UGDH. The antibody 1B7 can be used for immunoassay techniques such as: ELISA, WB.
See all UGDH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B7
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Ascites fluid

Target

Full Name
UDP-Glucose 6-Dehydrogenase
Introduction
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Entrez Gene ID
7358
UniProt ID
O60701
Alternative Names
UDP-Glucose 6-Dehydrogenase; UDP-Glucose Dehydrogenase; UDP-Glc Dehydrogenase; EC 1.1.1.22; UDP-GlcDH; UDPGDH; Uridine Diphospho-Glucose Dehydrogenase; GDH; UGD;
Function
Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329).
Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).
Required for proper brain and neuronal development (PubMed:32001716).
Biological Process
Biological Process carbohydrate metabolic process Source:UniProtKB-KW
Biological Process chondroitin sulfate biosynthetic process Source:UniProtKB
Biological Process gastrulation with mouth forming second Source:UniProtKB
Biological Process glycosaminoglycan biosynthetic process Source:GO_Central1 Publication
Biological Process heparan sulfate proteoglycan biosynthetic process Source:UniProtKB
Biological Process neuron development Source:UniProtKB1 Publication
Biological Process protein hexamerization Source:UniProtKB1 Publication
Biological Process UDP-glucuronate biosynthetic process Source:UniProtKB1 Publication
Cellular Location
cytosol
extracellular exosome
nucleoplasm
nucleus
Involvement in disease
Developmental and epileptic encephalopathy 84 (DEE84):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE84 is an autosomal recessive form characterized by onset of refractory seizures in the first months of life.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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