Mouse Anti-UGDH Recombinant Antibody (2G11) (CBMAB-C4534-CN)

Name: Mouse Anti-UGDH Recombinant Antibody (2G11)
SKU: CBMAB-C4534-CN
Rating: 5 (1 reviews)

See all UGDH antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2G11

Application

WB, FC, ELISA, IF

Immunogen

Recombinant human UGDH (aa 1-494) purified from E. coli

Specificity

Human, Mouse

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

UDP-Glucose 6-Dehydrogenase

Introduction

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Entrez Gene ID

Human	7358
Mouse	22235

UniProt ID

Human	O60701
Mouse	O70475

Alternative Names

UDP-Glucose 6-Dehydrogenase; UDP-Glucose Dehydrogenase; UDP-Glc Dehydrogenase; EC 1.1.1.22; UDP-GlcDH; UDPGDH; Uridine Diphospho-Glucose Dehydrogenase; GDH; UGD;

Function

Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (PubMed:21961565, PubMed:21502315, PubMed:23106432, PubMed:22123821, PubMed:25478983, PubMed:27966912, PubMed:30420606, PubMed:30457329).
Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).
Required for proper brain and neuronal development (PubMed:32001716).

Biological Process

Biological Process carbohydrate metabolic process Source:UniProtKB-KW
Biological Process chondroitin sulfate biosynthetic process Source:UniProtKB
Biological Process gastrulation with mouth forming second Source:UniProtKB
Biological Process glycosaminoglycan biosynthetic process Source:GO_Central1 Publication
Biological Process heparan sulfate proteoglycan biosynthetic process Source:UniProtKB
Biological Process neuron development Source:UniProtKB1 Publication
Biological Process protein hexamerization Source:UniProtKB1 Publication
Biological Process UDP-glucuronate biosynthetic process Source:UniProtKB1 Publication

Cellular Location

cytosol
extracellular exosome
nucleoplasm
nucleus

Involvement in disease

Developmental and epileptic encephalopathy 84 (DEE84):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE84 is an autosomal recessive form characterized by onset of refractory seizures in the first months of life.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-UGDH Recombinant Antibody (2G11)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-UGDH Recombinant Antibody (1B7) (CAT#: CBMAB-C4533-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry