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Mouse Anti-UHRF2 Recombinant Antibody (3A11) (CBMAB-C4581-CN)

This product is a Mouse antibody that recognizes UHRF2. The antibody 3A11 can be used for immunoassay techniques such as: WB.
See all UHRF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A11
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to aa 81 - 181 of human UHRF2
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative
No preservatives
Concentration
0.5 mg/mL

Target

Full Name
ubiquitin-like with PHD and ring finger domains 2
Introduction
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]
Entrez Gene ID
115426
UniProt ID
Q96PU4
Alternative Names
Ubiquitin Like With PHD And Ring Finger Domains 2; Np95-Like Ring Finger Protein; Ubiquitin-Like With PHD And Ring Finger Domains 2, E3 Ubiquitin Protein Ligase; Ubiquitin-Like-Containing PHD And RING Finger Domains Protein 2; Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 2; RING-Type E3 Ubiquitin Transferase UHRF2; Np95/ICBP90-Like RING Finger Protein; RING Finger Protein 107; Nuclear Protein 97; RNF107;
Function
E3 ubiquitin ligase that plays important roles in DNA methylation, histone modifications, cell cycle and DNA repair (PubMed:15178429, PubMed:29506131, PubMed:27743347, PubMed:23404503).
Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:27129234, PubMed:24813944).
This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity).
Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639).
Ubiquitinates also PCNP leading to its degradation by the proteasome (PubMed:14741369, PubMed:12176013).
Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteosomal degradation (PubMed:29923055).
Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751).
Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395).
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell differentiation Source:HGNC-UCL1 Publication
Biological Process maintenance of DNA methylation Source:GO_Central1 Publication
Biological Process protein autoubiquitination Source:HGNC-UCL1 Publication
Biological Process protein ubiquitination Source:HGNC-UCL1 Publication
Biological Process regulation of cell cycle Source:UniProtKB1 Publication
Cellular Location
Nucleus
Chromosome
Enriched at genomic loci that are enriched for 5-hydroxymethylcytosine (5hmC).
Involvement in disease
Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung.
PTM
May be autoubiquitinated; which may lead to proteasomal degradation.
Phosphorylated. Phosphorylation may be mediated by CDK2.
Autosumoylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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