Mouse Anti-UHRF2 Recombinant Antibody (CBFYU-251) (CBMAB-U0251-FY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Acts as a specific reader for 5-hydroxymethylcytosine (5hmC) and thereby recruits various substrates to these sites to ubiquitinate them (PubMed:27129234, PubMed:24813944).
This activity also allows the maintenance of 5mC levels at specific genomic loci and regulates neuron-related gene expression (By similarity).
Participates in cell cycle regulation by ubiquitinating cyclins CCND1 and CCNE1 and thereby inducing G1 arrest (PubMed:15178429, PubMed:15361834, PubMed:21952639).
Ubiquitinates also PCNP leading to its degradation by the proteasome (PubMed:14741369, PubMed:12176013).
Plays an active role in DNA damage repair by ubiquitinating p21/CDKN1A leading to its proteosomal degradation (PubMed:29923055).
Promotes also DNA repair by acting as an interstrand cross-links (ICLs) sensor. Mechanistically, cooperates with UHRF1 to ensure recruitment of FANCD2 to ICLs, leading to FANCD2 monoubiquitination and subsequent activation (PubMed:30335751).
Contributes to UV-induced DNA damage response by physically interacting with ATR in response to irradiation, thereby promoting ATR activation (PubMed:33848395).
Biological Process cell differentiation Source:HGNC-UCL1 Publication
Biological Process maintenance of DNA methylation Source:GO_Central1 Publication
Biological Process protein autoubiquitination Source:HGNC-UCL1 Publication
Biological Process protein ubiquitination Source:HGNC-UCL1 Publication
Biological Process regulation of cell cycle Source:UniProtKB1 Publication
Chromosome
Enriched at genomic loci that are enriched for 5-hydroxymethylcytosine (5hmC).
Phosphorylated. Phosphorylation may be mediated by CDK2.
Autosumoylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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