Mouse Anti-UMPS Recombinant Antibody (2B10) (CBMAB-C4647-CN)

Name: Mouse Anti-UMPS Recombinant Antibody (2B10)
SKU: CBMAB-C4647-CN
Rating: 5 (1 reviews)

See all UMPS antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2B10

Application

ELISA, IF, WB

Immunogen

UMPS (NP_000364, aa 381-479) partial recombinant protein with GST tag

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

More Infomation

Target

Full Name

uridine monophosphate synthetase

Introduction

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Entrez Gene ID

7372

UniProt ID

P11172

Alternative Names

Uridine Monophosphate Synthetase; UMP Synthase; Orotate Phosphoribosyl Transferase And Orotidine-5-Decarboxylase; Orotidine 5-Phosphate Decarboxylase; Orotate Phosphoribosyltransferase; Uridine 5-Monophosphate Synthase; OMPdecase; OPRTase; OPRT;

Function

Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).

Biological Process

Biological Process 'de novo' pyrimidine nucleobase biosynthetic process Source:InterPro
Biological Process 'de novo' UMP biosynthetic process Source:UniProtKB-UniPathway
Biological Process cellular response to xenobiotic stimulus Source:Ensembl
Biological Process female pregnancy Source:Ensembl
Biological Process lactation Source:Ensembl
Biological Process pyrimidine nucleobase biosynthetic process Source:GO_Central1 Publication
Biological Process UDP biosynthetic process Source:Ensembl
Biological Process UMP biosynthetic process Source:UniProtKB4 Publications

Cellular Location

cytoplasm
cytosol
nucleus

Involvement in disease

Orotic aciduria 1 (ORAC1):
A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and intellectual disability. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-UMPS Recombinant Antibody (2B10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-UMPS Recombinant Antibody (2F5) (CAT#: CBMAB-C4648-CN)

Mouse Anti-UMPS Recombinant Antibody (CBCNC-791) (CAT#: CBMAB-C4649-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry