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Mouse Anti-UMPS Recombinant Antibody (2F5) (CBMAB-C4648-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F5
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
UMPS (NP_000364, aa 381-480) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
uridine monophosphate synthetase
Introduction
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Entrez Gene ID
7372
UniProt ID
P11172
Alternative Names
Uridine Monophosphate Synthetase; UMP Synthase; Orotate Phosphoribosyl Transferase And Orotidine-5-Decarboxylase; Orotidine 5-Phosphate Decarboxylase; Orotate Phosphoribosyltransferase; Uridine 5-Monophosphate Synthase; OMPdecase; OPRTase; OPRT;
Function
Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP).
Biological Process
Biological Process 'de novo' pyrimidine nucleobase biosynthetic process Source:InterPro
Biological Process 'de novo' UMP biosynthetic process Source:UniProtKB-UniPathway
Biological Process cellular response to xenobiotic stimulus Source:Ensembl
Biological Process female pregnancy Source:Ensembl
Biological Process lactation Source:Ensembl
Biological Process pyrimidine nucleobase biosynthetic process Source:GO_Central1 Publication
Biological Process UDP biosynthetic process Source:Ensembl
Biological Process UMP biosynthetic process Source:UniProtKB4 Publications
Cellular Location
cytoplasm
cytosol
nucleus
Involvement in disease
Orotic aciduria 1 (ORAC1):
A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and intellectual disability. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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