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  • Mouse Anti-UNC13A Recombinant Antibody (CBFYM-3176)

Mouse Anti-UNC13A Recombinant Antibody (CBFYM-3176) (CBMAB-M3373-FY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBFYM-3176
Application
WB, ELISA
Specificity
Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
2.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
UNC-13 HOMOLOG A
Introduction
A large genome-wide screen in patients with sporadic amyotrophic lateral sclerosis showed that the common variant rs12608932 in gene UNC13A was associated with disease susceptibility.
Entrez Gene ID
Mouse382018
Rat64829
UniProt ID
MouseQ4KUS2
RatQ62768
Alternative Names
Munc13-1; 2410078G03Rik
Function
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity).
Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process dense core granule priming Source:GO_Central1 Publication
Biological Process neuromuscular junction development Source:GO_Central1 Publication
Biological Process neuronal dense core vesicle exocytosis Source:UniProtKB
Biological Process neurotransmitter secretion Source:ParkinsonsUK-UCL
Biological Process positive regulation of dendrite extension Source:UniProtKB1 Publication
Biological Process presynaptic dense core vesicle exocytosis Source:GO_Central1 Publication
Biological Process regulation of synaptic transmission, glutamatergic Source:ParkinsonsUK-UCL1 Publication
Biological Process synaptic transmission, glutamatergic Source:GO_Central1 Publication
Biological Process synaptic vesicle docking Source:GO_Central1 Publication
Biological Process synaptic vesicle maturation Source:GO_Central1 Publication
Biological Process synaptic vesicle priming Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Cell membrane
Presynaptic cell membrane
Presynaptic active zone
Translocated to the plasma membrane in response to phorbol ester binding.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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