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Mouse Anti-UNC45A Recombinant Antibody (AbS1) (CBMAB-C4660-CN)

This product is a Mouse antibody that recognizes UNC45A. The antibody AbS1 can be used for immunoassay techniques such as: WB.
See all UNC45A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
AbS1
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant human UNC45
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol
Preservative
0.09% Sodium azide

Target

Full Name
Unc-45 Myosin Chaperone A
Introduction
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor (PGR; MIM 607311) and HSP90 (HSPCA; MIM 140571), and acts as a regulator of the progesterone receptor chaperoning pathway (Price et al., 2002 [PubMed 12356907]; Chadli et al., 2006 [PubMed 16478993]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
Human55898
Mouse101869
Rat308759
UniProt ID
HumanQ9H3U1
MouseQ99KD5
RatQ32PZ3
Alternative Names
Unc-45 Myosin Chaperone A; Smooth Muscle Cell Associated Protein-1; GCUNC-45; UNC-45A; SMAP-1; SMAP1; Smooth Muscle Cell-Associated Protein 1; Unc-45 Homolog A (C. Elegans);
Function
Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).
Biological Process
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process chaperone-mediated protein folding Source:GO_Central1 Publication
Biological Process muscle organ development Source:UniProtKB-KW
Cellular Location
Cytoplasm
Cytoplasm, perinuclear region
Nucleus
Predominant in the perinuclear region. Little protein in the nucleus.
Involvement in disease
Osteootohepatoenteric syndrome (OOHE):
An autosomal recessive disorder characterized by cholestasis, congenital diarrhea, impaired hearing, and bone fragility. Some patients also display mild developmental delay and intellectual disability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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