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Mouse Anti-UNC45A Recombinant Antibody (CBYC-P858) (CBMAB-P3771-YC)

Provided herein is a Mouse monoclonal antibody against Human Unc-45 Myosin Chaperone A. The antibody can be used for immunoassay techniques, such as WB.
See all UNC45A antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYC-P858
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant human UNC45
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
50% glycerol and 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Unc-45 Myosin Chaperone A
Introduction
UNC45A plays a role in cell proliferation and myoblast fusion, binds progesterone receptor and HSP90, and acts as a regulator of the progesterone receptor chaperoning pathway.
Entrez Gene ID
Human55898
Mouse101869
Rat308759
UniProt ID
HumanQ9H3U1
MouseQ99KD5
RatQ32PZ3
Alternative Names
Unc-45 Myosin Chaperone A; Smooth Muscle Cell Associated Protein-1; GCUNC-45; UNC-45A; SMAP-1; SMAP1; Smooth Muscle Cell-Associated Protein 1; Unc-45 Homolog A (C. Elegans);
Function
Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity).
Biological Process
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process chaperone-mediated protein folding Source:GO_Central1 Publication
Biological Process muscle organ development Source:UniProtKB-KW
Cellular Location
Cytoplasm
Cytoplasm, perinuclear region
Nucleus
Predominant in the perinuclear region. Little protein in the nucleus.
Involvement in disease
Osteootohepatoenteric syndrome (OOHE):
An autosomal recessive disorder characterized by cholestasis, congenital diarrhea, impaired hearing, and bone fragility. Some patients also display mild developmental delay and intellectual disability.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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