Mouse Anti-UNG Recombinant Antibody (2B5) (CBMAB-C4683-CN)

Name: Mouse Anti-UNG Recombinant Antibody (2B5)
SKU: CBMAB-C4683-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2B5

Application

Immunogen

Full length human recombinant protein of human UNG(NP_550433) produced in HEK293T cell.ImmunogenType: Recombinant protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.82 mg/mL

More Infomation

Target

Full Name

uracil-DNA glycosylase

Introduction

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

Entrez Gene ID

7374

UniProt ID

P13051

Alternative Names

Uracil DNA Glycosylase; Uracil-DNA Glycosylase 1, Uracil-DNA Glycosylase 2; UNG15; UNG1; DGU; UDG; Uracil-DNA Glycosylase;

Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

Biological Process

Biological Process base-excision repair Source:HGNC1 Publication
Biological Process base-excision repair, AP site formation via deaminated base removal Source:UniProtKB1 Publication
Biological Process depyrimidination Source:Reactome
Biological Process DNA repair Source:ProtInc1 Publication
Biological Process isotype switching Source:Ensembl
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process somatic hypermutation of immunoglobulin genes Source:Ensembl

Cellular Location

Isoform 1
Mitochondrion
Isoform 2
Nucleus

Involvement in disease

Immunodeficiency with hyper-IgM 5 (HIGM5):
A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.

PTM

Isoform 1 is processed by cleavage of a transit peptide.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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