UNG

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. [provided by RefSeq]
Full Name
uracil-DNA glycosylase
Function
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Biological Process
Biological Process base-excision repair Source:HGNC1 Publication
Biological Process base-excision repair, AP site formation via deaminated base removal Source:UniProtKB1 Publication
Biological Process depyrimidination Source:Reactome
Biological Process DNA repair Source:ProtInc1 Publication
Biological Process isotype switching Source:Ensembl
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process somatic hypermutation of immunoglobulin genes Source:Ensembl
Cellular Location
Isoform 1
Mitochondrion
Isoform 2
Nucleus
Involvement in disease
Immunodeficiency with hyper-IgM 5 (HIGM5):
A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.
PTM
Isoform 1 is processed by cleavage of a transit peptide.
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Anti-UNG antibodies

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Mouse Anti-UNG Recombinant Antibody (8G6) (CBMAB-C4688-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 8G6
Application*: E, WB
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (4C12) (CBMAB-C4687-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4C12
Application*: E
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (2F3) (CBMAB-C4685-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2F3
Application*: IF, WB
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (2C12) (CBMAB-C4684-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2C12
Application*: IF
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (2B5) (CBMAB-C4683-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B5
Application*: IF
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (203627) (CBMAB-C4682-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 203627
Application*: WB
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (1G2) (CBMAB-C4681-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey
Clone: 1G2
Application*: IH, WB
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (1F8) (CBMAB-C4679-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1F8
Application*: IH, FC, WB
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (1B6) (CBMAB-C4678-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B6
Application*: IF, IH, WB
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (1A6) (CBMAB-C4677-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A6
Application*: WB
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (1A11) (CBMAB-C4676-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A11
Application*: WB, IH, E, P
Datasheet SDS

Mouse Anti-UNG Recombinant Antibody (k1C12) (CBMAB-C1040-CN)

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Target: UNG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: k1C12
Application*: E
Datasheet SDS

Rabbit Anti-UNG Recombinant Antibody (CBCNC-111) (CBMAB-C1039-CN)

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Target: UNG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBCNC-111
Application*: WB, P, FC, IF
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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