UNG

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. [provided by RefSeq]

Full Name

uracil-DNA glycosylase

Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

Biological Process

Biological Process base-excision repair Source:HGNC1 Publication
Biological Process base-excision repair, AP site formation via deaminated base removal Source:UniProtKB1 Publication
Biological Process depyrimidination Source:Reactome
Biological Process DNA repair Source:ProtInc1 Publication
Biological Process isotype switching Source:Ensembl
Biological Process negative regulation of apoptotic process Source:Ensembl
Biological Process somatic hypermutation of immunoglobulin genes Source:Ensembl

Cellular Location

Isoform 1
Mitochondrion
Isoform 2
Nucleus

Involvement in disease

Immunodeficiency with hyper-IgM 5 (HIGM5):
A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.

PTM

Isoform 1 is processed by cleavage of a transit peptide.

Anti-UNG antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-UNG Recombinant Antibody (8G6) (CBMAB-C4688-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 8G6

Application*: E, WB

Mouse Anti-UNG Recombinant Antibody (4C12) (CBMAB-C4687-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4C12

Application*: E

Mouse Anti-UNG Recombinant Antibody (2F3) (CBMAB-C4685-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2F3

Application*: IF, WB

Mouse Anti-UNG Recombinant Antibody (2C12) (CBMAB-C4684-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2C12

Application*: IF

Mouse Anti-UNG Recombinant Antibody (2B5) (CBMAB-C4683-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2B5

Application*: IF

Mouse Anti-UNG Recombinant Antibody (203627) (CBMAB-C4682-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 203627

Application*: WB

Mouse Anti-UNG Recombinant Antibody (1G2) (CBMAB-C4681-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Monkey

Clone: 1G2

Application*: IH, WB

Mouse Anti-UNG Recombinant Antibody (1F8) (CBMAB-C4679-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1F8

Application*: IH, FC, WB

Mouse Anti-UNG Recombinant Antibody (1B6) (CBMAB-C4678-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1B6

Application*: IF, IH, WB

Mouse Anti-UNG Recombinant Antibody (1A6) (CBMAB-C4677-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A6

Application*: WB

Mouse Anti-UNG Recombinant Antibody (1A11) (CBMAB-C4676-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A11

Application*: WB, IH, E, P

Mouse Anti-UNG Recombinant Antibody (k1C12) (CBMAB-C1040-CN)

Datasheet

SDS

Target: UNG

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: k1C12

Application*: E

Rabbit Anti-UNG Recombinant Antibody (CBCNC-111) (CBMAB-C1039-CN)

Datasheet

SDS

Target: UNG

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBCNC-111

Application*: WB, P, FC, IF

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)