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Rabbit Anti-UPF2 Recombinant Antibody (D3B10) (CBMAB-C4697-CN)

This product is a Rabbit antibody that recognizes UPF2. The antibody D3B10 can be used for immunoassay techniques such as: WB.
See all UPF2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D3B10
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
UPF2, Regulator Of Nonsense Mediated MRNA Decay
Introduction
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human26019
Mouse326622
Rat361271
Monkey693842
UniProt ID
HumanQ9HAU5
MouseA2AT37
RatD3ZT03
MonkeyF7HDY5
Alternative Names
UPF2, Regulator Of Nonsense Mediated MRNA Decay; Up-Frameshift Suppressor 2 Homolog; Nonsense MRNA Reducing Factor 2; HUPF2; RENT2; Smg-3 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans); UPF2 Regulator Of Nonsense Transcripts Homolog (Yeast); Smg-3 Homolog, Nonsense Mediated MRNA Decay Factor;
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.
Biological Process
Biological Process animal organ regeneration Source:Ensembl
Biological Process liver development Source:Ensembl
Biological Process mRNA export from nucleus Source:HGNC-UCL1 Publication
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, perinuclear region
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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