Mouse Anti-UPF2 Recombinant Antibody (G-10) (CBMAB-R4090-CN)

Name: Mouse Anti-UPF2 Recombinant Antibody (G-10)
SKU: CBMAB-R4090-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

G-10

Application

WB, IP, IF, ELISA

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

UPF2, Regulator Of Nonsense Mediated MRNA Decay

Introduction

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]

Entrez Gene ID

26019

UniProt ID

Q9HAU5

Alternative Names

UPF2, Regulator Of Nonsense Mediated MRNA Decay; Up-Frameshift Suppressor 2 Homolog; Nonsense MRNA Reducing Factor 2; HUPF2; RENT2; Smg-3 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans); UPF2 Regulator Of Nonsense Transcripts Homolog (Yeast); Smg-3 Homolog, Nonsense Mediated MRNA Decay Factor;

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.

Biological Process

Biological Process animal organ regeneration Source:Ensembl
Biological Process liver development Source:Ensembl
Biological Process mRNA export from nucleus Source:HGNC-UCL1 Publication
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source:UniProtKB1 Publication

Cellular Location

Cytoplasm, perinuclear region
Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

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Rabbit Anti-UPF2 Recombinant Antibody (D3B10) (CAT#: CBMAB-C4697-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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