Mouse Anti-UPF3A Recombinant Antibody (CBCNC-801) (CBMAB-C4700-CN)

Name: Mouse Anti-UPF3A Recombinant Antibody (CBCNC-801)
SKU: CBMAB-C4700-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBCNC-801

Application

WB, ELISA

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

UPF3 regulator of nonsense transcripts homolog A (yeast)

Introduction

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

Entrez Gene ID

65110

UniProt ID

Q9H1J1

Alternative Names

UPF3A, Regulator Of Nonsense Mediated MRNA Decay; Up-Frameshift Suppressor 3 Homolog A; Nonsense MRNA Reducing Factor 3A; RENT3A; HUpf3; UPF3;

Function

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.

Biological Process

Biological Process in utero embryonic development Source:Ensembl
Biological Process mRNA transport Source:UniProtKB-KW
Biological Process negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source:Ensembl
Biological Process positive regulation of translation Source:UniProtKB1 Publication
Biological Process spermatogenesis Source:Ensembl

Cellular Location

Nucleus
Cytoplasm
Shuttling between the nucleus and the cytoplasm.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-UPF3A Recombinant Antibody (2E2) (CAT#: CBMAB-C4698-CN)

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For research use only. Not intended for any clinical use.

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