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Rabbit Anti-UPK1B Recombinant Antibody (CBCNC-803) (CBMAB-C4704-CN)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBCNC-803
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide within Human Uroplakin Ib aa 1-100 (N terminal). The exact sequence is proprietary.
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.472 mg/mL

Target

Full Name
uroplakin 1B
Introduction
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human7348
Mouse22268
Rat303924
UniProt ID
HumanO75841
MouseQ9Z2C6
RatQ566D0
Alternative Names
Uroplakin 1B; Tetraspanin-20; Uroplakin Ib; Tspan-20; TSPAN20; UPIB;
Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
Biological Process
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process response to bacterium Source:Ensembl
Cellular Location
Membrane
Topology
Cytoplasmic: 1-15
Helical: 16-36
Extracellular: 37-60
Helical: 61-81
Cytoplasmic: 82-86
Helical: 87-107
Extracellular: 108-229
Helical: 230-250
Cytoplasmic: 251-260
PTM
N-glycosylated with high-mannose oligosaccharides.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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