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Mouse Anti-UPK1B Recombinant Antibody (CBYJT-5573) (CBMAB-T5206-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5573
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
uroplakin 1B
Introduction
UPK1B is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. It mediate signal transduction events that function in the regulation of cell development, activation, growth and motility. UPK1B is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may function in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.
Entrez Gene ID
7348
UniProt ID
O75841
Alternative Names
Uroplakin 1B; Tetraspanin-20; Uroplakin Ib; Tspan-20; TSPAN20; UPIB
Function
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).
Biological Process
Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process response to bacterium Source:Ensembl
Cellular Location
Membrane
Topology
Cytoplasmic: 1-15
Helical: 16-36
Extracellular: 37-60
Helical: 61-81
Cytoplasmic: 82-86
Helical: 87-107
Extracellular: 108-229
Helical: 230-250
Cytoplasmic: 251-260
PTM
N-glycosylated with high-mannose oligosaccharides.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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