Mouse Anti-UPK1B Recombinant Antibody (CBYJT-5573) (CBMAB-T5206-YJ)

Name: Mouse Anti-UPK1B Recombinant Antibody (CBYJT-5573)
SKU: CBMAB-T5206-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-5573

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

uroplakin 1B

Introduction

UPK1B is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. It mediate signal transduction events that function in the regulation of cell development, activation, growth and motility. UPK1B is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may function in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.

Entrez Gene ID

7348

UniProt ID

O75841

Alternative Names

Uroplakin 1B; Tetraspanin-20; Uroplakin Ib; Tspan-20; TSPAN20; UPIB

Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

Biological Process

Biological Process epithelial cell differentiation Source:UniProtKB1 Publication
Biological Process response to bacterium Source:Ensembl

Cellular Location

Membrane

Topology

Cytoplasmic: 1-15
Helical: 16-36
Extracellular: 37-60
Helical: 61-81
Cytoplasmic: 82-86
Helical: 87-107
Extracellular: 108-229
Helical: 230-250
Cytoplasmic: 251-260

PTM

N-glycosylated with high-mannose oligosaccharides.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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