Mouse Anti-USP21 (aa 466-566) Recombinant Antibody (CBXU-082) (CBMAB-U0185-CQ)

Name: Mouse Anti-USP21 (aa 466-566) Recombinant Antibody (CBXU-082)
SKU: CBMAB-U0185-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXU-082

Application

ELISA, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2a, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

1 mg/mL

Purity

>95% as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 466-566

More Infomation

Target

Full Name

ubiquitin specific peptidase 21

Introduction

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation.

Entrez Gene ID

27005

UniProt ID

Q9UK80

Alternative Names

USP16; USP23

Function

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity).
Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498).
Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).

Biological Process

Biological Process chromatin organization Source:UniProtKB-KW
Biological Process histone deubiquitination Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB
Biological Process protein deubiquitination Source:Reactome
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Cytoplasm
Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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