USP21

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq]
Full Name
ubiquitin specific peptidase 21
Function
Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity).
Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498).
Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).
Biological Process
Biological Process chromatin organization Source:UniProtKB-KW
Biological Process histone deubiquitination Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB
Biological Process protein deubiquitination Source:Reactome
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Cytoplasm
Nucleus
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Anti-USP21 antibodies

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Mouse Anti-USP21 Recombinant Antibody (CBXU-085) (CBMAB-U0187-CQ)

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Target: USP21
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXU-085
Application*: WB
Datasheet SDS

Mouse Anti-USP21 Recombinant Antibody (CBXU-084) (CBMAB-U0186-CQ)

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Target: USP21
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXU-084
Application*: WB
Datasheet SDS

Mouse Anti-USP21 (aa 466-566) Recombinant Antibody (CBXU-082) (CBMAB-U0185-CQ)

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Target: USP21
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXU-082
Application*: E, P, WB
Datasheet SDS

Mouse Anti-USP21 Recombinant Antibody (3D10) (CBMAB-U0071-CQ)

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Target: USP21
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3D10
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-USP21 Recombinant Antibody (CBXU-083) (CBMAB-U0003-CQ)

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Target: USP21
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXU-083
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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