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USP21

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq]

Full Name

ubiquitin specific peptidase 21

Function

Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity).
Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates (PubMed:10799498).
Deubiquitinates BAZ2A/TIP5 leading to its stabilization (PubMed:26100909).

Biological Process

Biological Process chromatin organization Source:UniProtKB-KW
Biological Process histone deubiquitination Source:UniProtKB
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB
Biological Process protein deubiquitination Source:Reactome
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Cytoplasm
Nucleus

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Anti-USP21 antibodies

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Mouse Anti-USP21 Recombinant Antibody (CBXU-085) (CBMAB-U0187-CQ)

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Target: USP21

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXU-085

Application*: WB

Mouse Anti-USP21 Recombinant Antibody (CBXU-084) (CBMAB-U0186-CQ)

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Target: USP21

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXU-084

Application*: WB

Mouse Anti-USP21 (aa 466-566) Recombinant Antibody (CBXU-082) (CBMAB-U0185-CQ)

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Target: USP21

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXU-082

Application*: E, P, WB

Mouse Anti-USP21 Recombinant Antibody (3D10) (CBMAB-U0071-CQ)

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Target: USP21

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 3D10

Application*: WB, IP, E

Mouse Anti-USP21 Recombinant Antibody (CBXU-083) (CBMAB-U0003-CQ)

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Target: USP21

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXU-083

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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