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Mouse Anti-USP6 (aa 2-90) Recombinant Antibody (1F5) (CBMAB-U0032-CQ)

This product is a mouse antibody that recognizes USP6 (aa 2-90). The antibody 1F5 can be used for immunoassay techniques such as: ELISA, WB.
See all USP6 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
1F5
Antibody Isotype
IgG2a, к
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to amino acids 2-90 from USP6 (NP_004496)
Specificity
Human, Mouse
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
None
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 2-90

Target

Full Name
ubiquitin specific peptidase 6 (Tre-2 oncogene)
Introduction
USP6 (Ubiquitin Specific Peptidase 6) is a Protein Coding gene. Diseases associated with USP6 include Pseudosarcomatous Fibromatosis and Fasciitis. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Arf6 signaling events. Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Entrez Gene ID
Human9098
Mouse57915
UniProt ID
HumanP35125
Alternative Names
HRP1; TRE2; TRE17; Tre-2; TRESMCR; USP6-short
Function
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Biological Process
Biological Process activation of GTPase activity Source:GO_Central1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:UniProtKB1 Publication
Biological Process regulation of vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Cell membrane
Cytoplasm
Endosome
Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
Involvement in disease
A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation (PubMed:15026324).
PTM
Monubiquitinated; ubiquitination is calmodulin and calcium dependent.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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