Mouse Anti-USP6 (aa 2-90) Recombinant Antibody (1F5) (CBMAB-U0032-CQ)

Name: Mouse Anti-USP6 (aa 2-90) Recombinant Antibody (1F5)
SKU: CBMAB-U0032-CQ
Rating: 5 (1 reviews)

See all USP6 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1F5

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to amino acids 2-90 from USP6 (NP_004496)

Specificity

Human, Mouse

Antibody Isotype

IgG2a, к

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

None

Purity

>95% as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 2-90

More Infomation

Target

Full Name

ubiquitin specific peptidase 6 (Tre-2 oncogene)

Introduction

USP6 (Ubiquitin Specific Peptidase 6) is a Protein Coding gene. Diseases associated with USP6 include Pseudosarcomatous Fibromatosis and Fasciitis. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and Arf6 signaling events. Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.

Entrez Gene ID

Human	9098
Mouse	57915

UniProt ID

Human

P35125

Alternative Names

HRP1; TRE2; TRE17; Tre-2; TRESMCR; USP6-short

Function

Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.

Biological Process

Biological Process activation of GTPase activity Source:GO_Central1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process protein modification process Source:UniProtKB1 Publication
Biological Process regulation of vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Cell membrane
Cytoplasm
Endosome
Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.

Involvement in disease

A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation (PubMed:15026324).

PTM

Monubiquitinated; ubiquitination is calmodulin and calcium dependent.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-USP6 (aa 2-90) Recombinant Antibody (1F5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-USP6 Recombinant Antibody (CBXU-104) (CAT#: CBMAB-U0200-CQ)

Human Anti-USP6 Recombinant Antibody (
3C3G2) (CAT#: V2LY-0725-LY180)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry