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Mouse Anti-USP9Y Recombinant Antibody (CBXU-127) (CBMAB-U0210-CQ)

This product is a mouse antibody that recognizes USP9Y. The antibody CBXU-127 can be used for immunoassay techniques such as: WB.
See all USP9Y antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXU-127
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
>95% as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)
Introduction
This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Diseases associated with USP9Y include Spermatogenic Failure, Y-Linked, 2 and Male Infertility. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis.
Entrez Gene ID
8287
UniProt ID
O00507
Alternative Names
DFFRY; SPGFY2
Function
May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).
Biological Process
Biological Process BMP signaling pathway Source:UniProtKB
Biological Process cell migration Source:GO_Central1 Publication
Biological Process protein deubiquitination Source:UniProtKB
Biological Process spermatogenesis Source:ProtInc1 Publication
Biological Process transforming growth factor beta receptor signaling pathway Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Cytoplasm
Involvement in disease
Spermatogenic failure Y-linked 2 (SPGFY2):
A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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