USP9Y

This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq]

Full Name

ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)

Function

May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).

Biological Process

Biological Process BMP signaling pathway Source:UniProtKB
Biological Process cell migration Source:GO_Central1 Publication
Biological Process protein deubiquitination Source:UniProtKB
Biological Process spermatogenesis Source:ProtInc1 Publication
Biological Process transforming growth factor beta receptor signaling pathway Source:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Cellular Location

Cytoplasm

Involvement in disease

Spermatogenic failure Y-linked 2 (SPGFY2):
A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility.