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Mouse Anti-VAMP1 Recombinant Antibody (CBXS-0941) (CBMAB-S3855-CQ)

This product is a mouse antibody that recognizes VAMP1. The antibody CBXS-0941 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all VAMP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0941
Antibody Isotype
IgG1
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.1% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Vesicle Associated Membrane Protein 1
Introduction
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined.
Entrez Gene ID
6843
UniProt ID
P23763
Alternative Names
Vesicle Associated Membrane Protein 1; VAMP-1; SYB1; Vesicle-Associated Membrane Protein 1 (Synaptobrevin 1); Vesicle-Associated Membrane Protein 1; Synaptobrevin 1; Synaptobrevin-1; SPAX1;
Function
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Biological Process
Biological Process SNARE complex assembly Source:GO_Central1 Publication
Biological Process vesicle fusion Source:GO_Central1 Publication
Cellular Location
Isoform 1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Isoform 2
Cytoplasmic vesicle membrane
Synapse, synaptosome
Isoform 3
Mitochondrion outer membrane
Involvement in disease
Spastic ataxia 1, autosomal dominant (SPAX1):
An autosomal dominant form of spastic ataxia, a progressive neurodegenerative disorder characterized by lower-limb spasticity and generalized ataxia with dysarthria, impaired ocular movements, and gait disturbance.
Myasthenic syndrome, congenital, 25, presynaptic (CMS25):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features include easy fatigability and muscle weakness. CMS25 is an autosomal recessive form characterized by hypotonia and generalized muscle weakness apparent from birth. Affected individuals have feeding difficulties and delayed motor development, usually never achieving independent ambulation. Additional variable features include eye movement abnormalities, joint contractures, and rigid spine.
Topology
Cytoplasmic: 1-96
Helical: 97-116
Vesicular: 117-118
PTM
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which probably hydrolyzes the 78-Gln-|-Phe-79 bond and inhibits neurotransmitter release (PubMed:22289120).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 61-Arg-|-Leu-62 bond and inhibits neurotransmitter release (PubMed:22289120).
BoNT/D has low catalytic activity on this protein due to its sequence (PubMed:22289120).
Note that humans are not known to be infected by C.botulinum type D.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which probably hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release (PubMed:22289120).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which probably hydrolyzes the 68-Arg-|-Ala-69 bond and inhibits neurotransmitter release (PubMed:29540745).
It remains unknown whether BoNT/X is ever produced, or what organisms it targets.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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