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VAMP1

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]
Full Name
Vesicle Associated Membrane Protein 1
Function
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Biological Process
Biological Process SNARE complex assembly Source:GO_Central1 Publication
Biological Process vesicle fusion Source:GO_Central1 Publication
Cellular Location
Isoform 1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Synapse, synaptosome
Isoform 2
Cytoplasmic vesicle membrane
Synapse, synaptosome
Isoform 3
Mitochondrion outer membrane
Involvement in disease
Spastic ataxia 1, autosomal dominant (SPAX1):
An autosomal dominant form of spastic ataxia, a progressive neurodegenerative disorder characterized by lower-limb spasticity and generalized ataxia with dysarthria, impaired ocular movements, and gait disturbance.
Myasthenic syndrome, congenital, 25, presynaptic (CMS25):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features include easy fatigability and muscle weakness. CMS25 is an autosomal recessive form characterized by hypotonia and generalized muscle weakness apparent from birth. Affected individuals have feeding difficulties and delayed motor development, usually never achieving independent ambulation. Additional variable features include eye movement abnormalities, joint contractures, and rigid spine.
Topology
Cytoplasmic: 1-96
Helical: 97-116
Vesicular: 117-118
PTM
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which probably hydrolyzes the 78-Gln-|-Phe-79 bond and inhibits neurotransmitter release (PubMed:22289120).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which probably hydrolyzes the 61-Arg-|-Leu-62 bond and inhibits neurotransmitter release (PubMed:22289120).
BoNT/D has low catalytic activity on this protein due to its sequence (PubMed:22289120).
Note that humans are not known to be infected by C.botulinum type D.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which probably hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release (PubMed:22289120).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which probably hydrolyzes the 68-Arg-|-Ala-69 bond and inhibits neurotransmitter release (PubMed:29540745).
It remains unknown whether BoNT/X is ever produced, or what organisms it targets.

Anti-VAMP1 antibodies

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Target: VAMP1
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 5A4
Application*: WB, E
Target: VAMP1
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 5F3
Application*: WB, E
Target: VAMP1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Mouse, Monkey, Pig, Rat, Guinea pig, Hamster, Rabbit, Sheep, Frog, Cattle
Clone: CBXS-5688
Application*: WB
Target: VAMP1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Mouse, Pig, Rat, Hamster, Rabbit, Cattle
Clone: SP10
Application*: E, F, IP, WB
Target: VAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig
Clone: SP11
Application*: E, P, WB
Target: VAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: Syn-58
Application*: ELISA, WB, IHC
Target: VAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Mouse
Clone: CBXS-0939
Application*: IC, WB
Target: VAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0940
Application*: E, C, P, WB
Target: VAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0941
Application*: E, P, WB
Target: VAMP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: SP-11
Application*: E, C, P, WB
Target: VAMP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0330
Application*: WB, P, IF
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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