Mouse Anti-VAMP7 Monoclonal Antibody (549115) (CBMAB-1697-YC)

Name: Mouse Anti-VAMP7 Monoclonal Antibody (549115)
SKU: CBMAB-1697-YC
Rating: 5 (1 reviews)

See all VAMP7 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

549115

Application

IHC, WB

Immunogen

E. coli-derived recombinant human VAMP‑7 Ala2-Met140.

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Vesicle Associated Membrane Protein 7

Introduction

VAMP7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.

Entrez Gene ID

6845

UniProt ID

P51809

Alternative Names

SYBL1; TIVAMP; VAMP-7; TI-VAMP

Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.

Biological Process

Biological Process calcium-ion regulated exocytosis Source:UniProtKBBy Similarity
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKBBy Similarity
Biological Process endosome to lysosome transport Source:UniProtKB1 Publication
Biological Process eosinophil degranulation Source:UniProtKB1 Publication
Biological Process exocytosis Source:GO_Central1 Publication
Biological Process natural killer cell degranulation Source:UniProtKB1 Publication
Biological Process neutrophil degranulation Source:UniProtKB1 Publication
Biological Process phagocytosis, engulfment Source:UniProtKBBy Similarity
Biological Process positive regulation of histamine secretion by mast cell Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process vesicle fusion Source:UniProtKB1 Publication
Biological Process vesicle-mediated transport Source:UniProtKB1 Publication

Cellular Location

Cytoplasmic vesicle, secretory vesicle membrane
Golgi apparatus, trans-Golgi network membrane
Late endosome membrane
Lysosome membrane
Endoplasmic reticulum membrane
Cytoplasmic vesicle, phagosome membrane
Synapse, synaptosome
In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).

Topology

Cytoplasmic: 2-188
Helical: 189-209
Vesicular: 210-220

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-VAMP7 Monoclonal Antibody (549115)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-VAMP7 Recombinant Antibody (CBXS-3737) (CAT#: CBMAB-S1012-CQ)

Mouse Anti-VAMP7 Monoclonal Antibody (158.2) (CAT#: CBMAB-1698-YC)

Rabbit Anti-VAMP7 Recombinant Antibody (D4D5J) (CAT#: CBMAB-CP2963-LY)

Rabbit Anti-VAMP7 Recombinant Antibody (D8Y1R) (CAT#: CBMAB-CP2964-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry