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Mouse Anti-VAMP7 Monoclonal Antibody (549115) (CBMAB-1697-YC)

Provided herein is a mouse monoclonal antibody against Human VAMP7. The antibody, clone 549115, can be used for immunoassay techniques, such as IHC and WB.
See all VAMP7 antibodies
Published Data
Fig.1 VAMP7 knockdown efficiency was detected by western blotting.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
549115
Antibody Isotype
IgG2a
Application
IHC, WB

Basic Information

Immunogen
E. coli-derived recombinant human VAMP‑7 Ala2-Met140.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Vesicle Associated Membrane Protein 7
Introduction
VAMP7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.
Entrez Gene ID
6845
UniProt ID
P51809
Alternative Names
SYBL1; TIVAMP; VAMP-7; TI-VAMP
Function
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.
Biological Process
Biological Process calcium-ion regulated exocytosis Source:UniProtKBBy Similarity
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKBBy Similarity
Biological Process endosome to lysosome transport Source:UniProtKB1 Publication
Biological Process eosinophil degranulation Source:UniProtKB1 Publication
Biological Process exocytosis Source:GO_Central1 Publication
Biological Process natural killer cell degranulation Source:UniProtKB1 Publication
Biological Process neutrophil degranulation Source:UniProtKB1 Publication
Biological Process phagocytosis, engulfment Source:UniProtKBBy Similarity
Biological Process positive regulation of histamine secretion by mast cell Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process vesicle fusion Source:UniProtKB1 Publication
Biological Process vesicle-mediated transport Source:UniProtKB1 Publication
Cellular Location
Cytoplasmic vesicle, secretory vesicle membrane
Golgi apparatus, trans-Golgi network membrane
Late endosome membrane
Lysosome membrane
Endoplasmic reticulum membrane
Cytoplasmic vesicle, phagosome membrane
Synapse, synaptosome
In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).
Topology
Cytoplasmic: 2-188
Helical: 189-209
Vesicular: 210-220
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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