VAMP7

This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Full Name

Vesicle Associated Membrane Protein 7

Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.

Biological Process

Biological Process calcium-ion regulated exocytosis Source:UniProtKBBy Similarity
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKBBy Similarity
Biological Process endosome to lysosome transport Source:UniProtKB1 Publication
Biological Process eosinophil degranulation Source:UniProtKB1 Publication
Biological Process exocytosis Source:GO_Central1 Publication
Biological Process natural killer cell degranulation Source:UniProtKB1 Publication
Biological Process neutrophil degranulation Source:UniProtKB1 Publication
Biological Process phagocytosis, engulfment Source:UniProtKBBy Similarity
Biological Process positive regulation of histamine secretion by mast cell Source:UniProtKB1 Publication
Biological Process protein transport Source:UniProtKB-KW
Biological Process vesicle fusion Source:UniProtKB1 Publication
Biological Process vesicle-mediated transport Source:UniProtKB1 Publication

Cellular Location

Cytoplasmic vesicle, secretory vesicle membrane
Golgi apparatus, trans-Golgi network membrane
Late endosome membrane
Lysosome membrane
Endoplasmic reticulum membrane
Cytoplasmic vesicle, phagosome membrane
Synapse, synaptosome
In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).

Topology

Cytoplasmic: 2-188
Helical: 189-209
Vesicular: 210-220