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Rabbit Anti-VANGL1 Recombinant Antibody (D1J7X) (CBMAB-CP2965-LY)

The product is antibody recognizes VANGL1. The antibody D1J7X immunoassay techniques such as: WB.
See all VANGL1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Hamster, Monkey, Chicken, Cattle, Pig, Horse
Clone
D1J7X
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu309 of human VANGL1 protein.
Specificity
Human, Mouse, Rat, Hamster, Monkey, Chicken, Cattle, Pig, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
VANGL Planar Cell Polarity Protein 1
Introduction
This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Entrez Gene ID
Human81839
Mouse229658
Rat690366
Monkey709730
Cattle513056
Pig100157791
Hamster100750491
Chicken418337
Horse100059585
UniProt ID
HumanQ8TAA9
MouseQ80Z96
RatD3ZKC8
MonkeyH9YZ43
CattleE1BNR7
PigF1SAW7
HamsterA0A061IQ70
ChickenE1C1K5
HorseF6TBH7
Alternative Names
VANGL Planar Cell Polarity Protein 1; Vang-Like 1 (Van Gogh; Drosophila); Loop-Tail Protein 2 Homolog; Van Gogh-Like Protein 1; Strabismus 2; LPP2; STB2;
Biological Process
Biological Process pigmentation Source:Ensembl
Biological Process Wnt signaling pathway, planar cell polarity pathway Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Cell membrane
Involvement in disease
Neural tube defects (NTD):
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
Sacral defect with anterior meningocele (SDAM):
Form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant.
Topology
Cytoplasmic: 1-117
Helical: 118-138
Extracellular: 139-151
Helical: 152-172
Cytoplasmic: 173-182
Helical: 183-203
Extracellular: 204-222
Helical: 223-243
Cytoplasmic: 244-524
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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