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Rabbit Anti-VANGL1 Recombinant Antibody (BA0104) (CBMAB-0943CQ)

This product is a rabbit antibody that recognizes VANGL1. The antibody BA0104 can be used for immunoassay techniques such as: WB.
See all VANGL1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0104
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide within Human VANGL1 aa 200-300 (internal sequence) (Cysteine residue)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
VANGL Planar Cell Polarity Protein 1
Introduction
This gene encodes a member of the tretraspanin family. Diseases associated with VANGL1 include Caudal Regression Syndrome and Neural Tube Defects. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Wnt / Hedgehog / Notch. An important paralog of this gene is VANGL2.
Entrez Gene ID
Human81839
Mouse229658
Rat690366
UniProt ID
HumanQ8TAA9
MouseQ80Z96
RatD3ZKC8
Alternative Names
LPP2; STB2; STBM2; KITENIN
Biological Process
Biological Process pigmentation Source:Ensembl
Biological Process Wnt signaling pathway, planar cell polarity pathway Source:ParkinsonsUK-UCL1 Publication
Cellular Location
Cell membrane
Involvement in disease
Neural tube defects (NTD):
Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
Sacral defect with anterior meningocele (SDAM):
Form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant.
Topology
Cytoplasmic: 1-117
Helical: 118-138
Extracellular: 139-151
Helical: 152-172
Cytoplasmic: 173-182
Helical: 183-203
Extracellular: 204-222
Helical: 223-243
Cytoplasmic: 244-524
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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