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Mouse Anti-VAPA Recombinant Antibody (4C12) (CBMAB-A9852-LY)

The product is antibody recognizes VAPA. The antibody 4C12 immunoassay techniques such as: WB, ELISA.
See all VAPA antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
VAPA (AAH02992, 1 a.a. ~ 242 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
Introduction
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq]
Entrez Gene ID
9218
UniProt ID
Q9P0L0
Alternative Names
MGC3745; VAP-33; VAP-A; VAP33; hVAP-33
Function
Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites (PubMed:25447204).
The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:25447204).
With OSBPL3, may regulate ER morphology (PubMed:16143324).
May play a role in vesicle trafficking (PubMed:11511104, PubMed:19289470).
Biological Process
Biological Process cell death Source:UniProtKB1 Publication
Biological Process ceramide transport Source:ComplexPortal1 Publication
Biological Process COPII-coated vesicle budding Source:UniProtKB1 Publication
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport Source:UniProtKB1 Publication
Biological Process membrane fusion Source:ProtInc1 Publication
Biological Process negative regulation by host of viral genome replication Source:AgBase1 Publication
Biological Process neuron projection development Source:UniProtKB1 Publication
Biological Process phospholipid transport Source:ComplexPortal1 Publication
Biological Process positive regulation by host of viral genome replication Source:AgBase1 Publication
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signaling Source:UniProtKB1 Publication
Biological Process protein localization to endoplasmic reticulum Source:UniProtKB1 Publication
Biological Process sphingomyelin biosynthetic process Source:ComplexPortal1 Publication
Biological Process sterol transport Source:ComplexPortal1 Publication
Biological Process viral release from host cell Source:AgBase1 Publication
Cellular Location
Endoplasmic reticulum membrane
Cell membrane
Cell junction, tight junction
Nucleus membrane
Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells.
Topology
Cytoplasmic: 2-227
Helical: 228-248
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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